Page 0011

vii. References

1. Jones, C., Perryman, L. & Hargrave, D. Paediatric and adult malignant glioma: close relatives

or distant cousins? Nat Rev Clin Oncol 9, 400-13 (2012).

2. Sturm, D. et al. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat

Rev Cancer 14, 92-107 (2014).

3. Schwartzentruber, J. et al. Driver mutations in histone H3.3 and chromatin remodelling genes

in paediatric glioblastoma. Nature 482, 226-31 (2012).

4. Wu, X. et al. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature

482, 529-33 (2012).

5. Bjerke, L. et al. Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of

MYCN. Cancer Discov (2013).

6. Sturm, D. et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological

subgroups of glioblastoma. Cancer Cell 22, 425-37 (2012).

7. Taylor, K.e.a. Recurrent activating ACVR1/ALK2 mutations in diffuse intrinsic pontine glioma.

Nature Genetics (2014).

8. Buczkowicz, P., Hoeman, C., et al., . Comprehensive genomic analysis of diffuse intrinsic

pontine gliomas unravels three molecular subgroups and a novel cancer driver ACVR1. Nature

Genetics (2014).

9. Wu, G., Diaz, A. K., et al., . The genomic landscape of diffuse intrinsic pontine glioma and

pediatric non-brainstem high-grade glioma. Nature Genetics (2014).

10. Popov, S. et al. IDH1-associated primary glioblastoma in young adults displays differential

patterns of tumour and vascular morphology. PLoS One 8, e56328 (2013).

11. Little, S.E. et al. Receptor tyrosine kinase genes amplified in glioblastoma exhibit a mutual

exclusivity in variable proportions reflective of individual tumor heterogeneity. Cancer Res 72,

1614-20 (2012).

12. Szerlip, N.J. et al. Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA

amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc

Natl Acad Sci U S A 109, 3041-6 (2012).

13. Snuderl, M. et al. Mosaic amplification of multiple receptor tyrosine kinase genes in

glioblastoma. Cancer Cell 20, 810-7 (2011).

14. Gerlinger, M. et al. Genomic architecture and evolution of clear cell renal cell carcinomas

defined by multiregion sequencing. Nat Genet (2014).

15. Gerlinger, M. et al. Intratumor heterogeneity and branched evolution revealed by multiregion

sequencing. N Engl J Med 366, 883-92 (2012).

16. Swanton, C. Intratumor heterogeneity: evolution through space and time. Cancer Res 72,

4875-82 (2012).

17. Sottoriva, A. et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary

dynamics. Proc Natl Acad Sci U S A 110, 4009-14 (2013).

18. Johnson, B.E. et al. Mutational analysis reveals the origin and therapy-driven evolution of

recurrent glioma. Science 343, 189-93 (2014).

19. Monje, M. et al. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine

glioma. Proc Natl Acad Sci U S A 108, 4453-8 (2011).

20. Burford, A. et al. Distinct phenotypic differences associated with differential amplification of

receptor tyrosine kinase genes at 4q12 in glioblastoma. PLoS One 8, e71777 (2013).

21. Melchor, L. Leukemia (2014).

22. Potter, N.E. et al. Single-cell mutational profiling and clonal phylogeny in cancer. Genome Res

23, 2115-25 (2013).

23. Galli, R. et al. Isolation and characterization of tumorigenic, stem-like neural precursors from

human glioblastoma. Cancer Res 64, 7011-21 (2004).

24. Pollard, S.M. et al. Glioma stem cell lines expanded in adherent culture have tumor-specific

phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 4, 568-80 (2009).

25. Lee, J. et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more

closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.

Cancer Cell 9, 391-403 (2006).

26. Vinci, M. et al. Advances in establishment and analysis of three-dimensional tumor spheroidbased

functional assays for target validation and drug evaluation. BMC Biol 10, 29 (2012).

27. Vinci, M., Box, C., Zimmermann, M. & Eccles, S.A. Tumor spheroid-based migration assays for

evaluation of therapeutic agents. Methods Mol Biol 986, 253-66 (2013).

Index

  1. Page 0011
  2. Page 0011
  3. Page 0011
  4. Page 0011
  5. Page 0011
  6. Page 0011
  7. Page 0011
  8. Page 0011
  9. Page 0011
  10. Page 0011
  11. Page 0011
  12. Page 0011

Related Issues

powered by PageTiger