Page 0041

Table 1: The distribution of ethnicities of human cell lines offered by

ECACC categorized by cancer type. Of the thirty-eight cell lines listed,

representation for Blacks is 0%. ECACC also has other categories of

human cell lines not shown in the table, serum free (4), induced pluripotent

stem cells (1700), GPCR, Hybridoma collection (400), Chromosomal

abnormality, HLA-Type Collection (430) and Human Random Collection,

(700 all Caucasian)

Cancer Ethnicity

Colorectal

GP5d Caucasian

MDST8 Unknown

HCA-46 Unknown

HCA-24 Unknown

HCA-2 Unknown

HCA-7 Unknown

HCA-7 Colony 29 Unknown

HT29 gluc C1 Caucasian

HT115 Unknown

HT55 Unknown

HT29/219 Caucasian

CACO-2 Caucasian

LS180 Caucasian

SW 620 Caucasian

LoVo Unknown

LS174T Caucasian

COLO 320DM Caucasian

COLO 205 Caucasian

SW 1116 Caucasian

Neurobiology

BE(2)-C Caucasian

BE(2)-M17 Caucasian

SK-N-BE(2) Caucasian

SK-N-DZ Unknown

SH-SY5Y Unknown

Oesophageal

ESO26 Caucasian

ESO51 Caucasian

KYAE-1 Caucasian

KYSE-270 Asian

KYSE-30 Asian

KYSE-410 Asian

KYSE-70 Asian

OACM5.1 C Caucasian

OACP4 C Caucasian

OE19 Caucasian

OE21 Caucasian

OE33 Caucasian

SK-GT-2 Hispanic

SK-GT-4 Caucasian

RESEARCH AND DEVELOPMENT

41 CANCER CONTROL 2021

are used in drug discovery, this begins to explain the enhanced

responsiveness to chemotherapy drugs experienced among

Whites compared to Blacks (10,11). Of note, is that majority

of prostate cancer deaths occur among men with advanced

disease.

The other cancer with a focused attention on its disparity

is breast. Unlike prostate, the incidence rate for breast

cancer among African American women is lower than White

American women, yet the mortality rates are higher among

Black women. Of concern is that no treatments existed for the

most aggressive breast cancer, triple-negative breast cancer

(TNBC) until recently, the most common type of breast cancer

in Black women with 30% higher incidence rates (12) and

42% higher mortality rates (13). A similar pattern is observed

for the availability of breast cancer cell lines, although

representation for Blacks is observed among the six-breast

cancer cell line panels on ATCC, more TNBC panels are needed

for Black women with TNBC. TNBC cell line panel for Blacks

is approximately 20% and there is a 14% representation for

breast cancer cell lines overall. A larger gap was observed for

breast cancer cell lines offered by ECACC as 94% were of

European ethnicity and the remaining for Blacks. Similarly,

poor representation of Blacks is observed at clinical trial

accounting for less than 10% in general even for trials geared

at TNBC (14).

The other cancer of concern for both Black men and women is

lung cancer and like prostate cancer, there is an overall reduction

in incidence and mortality rates, but Blacks have roughly twice

higher incidence rates than Whites and higher mortality rates

(15). While socioeconomic factors play a large role in this, with

Blacks being less likely to receive optimal treatments including

surgeries compared to Whites (16,17), research has linked

biological drivers that contribute to the disparities(18). There

is evidence that Blacks experience inferior treatment response

to chemotherapy drugs and more severe toxicity to platinum5

8

15

71

Radiotherapy (73/114)

10

9

8

7

6

5

4

3

2

1

0

Number of cell lines

Percentage of registries

Less than

25%

25-49% 50-74% 75-100%

Tissue type

■ Asian ■ Black ■ Caucasian ■ Unknown

Colon

Breast

Bladder

Bone

Brain I

Brain II

Ovarian

Uterine

Gyneocological

Head and Neck

Leukaemia I

Leukaemia II

Lymphoma I

Lymphoma II

Lymphoma III

Liver

Lung I

Lung II

Melanoma I

Melanoma II

Pancreatic I

Pancreatic II

Sarcoma

Stomach

Figure 1: The ethnic representation of panels of cancer cell lines according to tissue specificity on ATCC's website. Taken from Badal et al., (9)

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