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3

CONTENTS

Definition of terms 5

CHAPTER 1: The lay member"s role 7

Defining a lay member

Benefits of lay participation

Lay involvement in other similar contexts

Becoming a lay member

Consensus, compromise and disagreement

CHAPTER 2: Finding out about the ERB 11

Level and scope of ethical review by the ERB

The ERB"s aims and tasks

Participants in the ERB

Authority of the ERB

For institutional ERBs

The wider context in which the ERB operates

Communication and evaluation of the ERB

CHAPTER 3: The Three Rs 16

What lay members should expect

Approaches to each "R": Replacement

Reduction

Refinement

Advancing the 3Rs in practice

Sources of further information

CHAPTER 4: Reviewing project applications 25

The ERB"s role in project review

What lay members should expect

Key steps in project review:

1. Gathering information

2. Questions and discussions

Assessing benefits

Assessing harms to animals

3. Drawing conclusions

More general questions underlying harm-benefit

Index

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