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EARLY DETECTION

vital support and collaboration. Hospital, Gulu (Uganda). In 1998 he was appointed Associate

Professor, Institute of Pathological Anatomy and Histology,

Professor Lorenzo Leoncini did his internship at the Institute of University of Sassari and from 2000 he has been a full professor

Pathological Anatomy and Histology, University of Siena and at the Department of Human Pathology and Oncology, Section

was awarded his medical degree in 1978 after which he chose of Pathological Anatomy, University of Siena. Professor

to specialize in pathology receiving his second degree from the Leoncini’s professional memberships include the European

University of Bari in 1982. He has had gained a wide experience Society of Pathology, International Academy of Pathology,

through his research and diagnositic activities at the Institute European Society for Haematopathology (where he has been a

of Pathology of the University of Bern (CH), Institute “Gustave Board member since 2002), Italian Society for Molecular

Roussy” Paris, Institute of Pathology of the Free University of Biology, International Society of Diagnostic and Quantitative

Berlin, Department of Immunology of the University of Cape Pathology and the American Association for Cancer Research.

Town, Institute of Human Pathology, University of Nairobi He is the author of over 70 articles in peer reviewed journals.

(Kenya), Bugando Medical Center, Mwanza (Tanzania), Lacor

References

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WHO Classification of lymphoid tumors, 2008 IARC Press. W. Mwanda, C. Bellan, M. Hummel, S. Pileri, P. Tosi, H. Stein, A. Giordano and L. Leoncini:

2.

Naresh KN, Raphael M, Ayers L, Hurwitz N, Calbi V, Rogena E, Sayed S, Sherman O, Gene expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt’s

Ibrahim HA, Lazzi S, Mourmouras V, Rince P, Githanga J, Byakika B, Moshi E, Durosinmi lymphoma cell lines and primary tumors. Blood 2007, 110:1301-7.

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M, Olasode BJ, Oluwasola OA, Akang EE, Akenòva Y, Adde M, Magrath I, Leoncini L. Leucci E, Cocco M, Onnis A, De Falco G, van Cleef P, Bellan C, van Rijk A, Nyagol J,

Lymphomas in sub-Saharan Africa - what can we learn and how can we help in improving Byakika B, Lazzi S, Tosi P, van Krieken H, Leoncini L. MYC-negative classical Burkitt

diagnosis, managing patients and fostering translational research? Br J Haematol. 2011 Lymphoma cases: an alternative pathogenetic mechanism involving miRNA

Jun 28. [Epub ahead of print] deregulation. J Pathol 2008, 216:440-50.

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Naresh KN, Ibrahim HA, Lazzi S, Rince P, Onorati M, Ambrosio MR, Bilhou-Nabera C, Anna Onnis, Giulia De Falco, Giuseppina Antonicelli, Monica Onorati, Benedetta Rossi,

Amen F, Reid A, Mawanda M, Calbi V, Ogwang M, Rogena E, Byakika B, Sayed S, Moshi E, Cristiana Bellan, Joshua Nyagol, Bessie Byakika and Lorenzo Leoncini. microRNA altered

Mwakigonja A, Raphael M, Magrath I, Leoncini L. Diagnosis of Burkitt lymphoma using expression as an alternative mechanism of MYC dysregulation in aggressive B-cell

an algorithmic approach - applicable in both resource-poor and resource-rich countries. lymphoma. PloS ONE 2010, 5:piie12960.

Br J Haematol. 2011 Jul 1. [Epub ahead of print] 20.

Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004,

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Cristiana Bellan, Stefano Lazzi, Giulia De Falco, Emily A. Rogena and Lorenzo Leoncini. 116:281-97.

Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach. 21.

He L and Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev

Hematological Oncology 2010, 28:53-56. Genet 2004, 5:522-31.

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Cullen BR. Transcription and processing of human microRNA precursors. Mol Cell

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Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently

malaria-endemic areas. Scand J Immunol 2005, 61: 461-5. located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA

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Moormann AM, Chelimo K, Sumba OP et al. Exposure to holoendemic malaria results in 2004, 101:2999-3004.

elevated Epstein-Barr virus loads in children. J Infect Dis 2005, 191:1233-8. 24.

Lu J, Getz G, Miska EA, et al.. MicroRNA expression profiles classify human cancers.

8.

Mutalima N, Molyneux E, Jaffe H et al. Associations between Burkitt Lymphoma among Nature 2005, 435:834-8.

Children in Malawi and Infection with HIV, EBV and Malaria: Results from a Case- 25.

Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid

Control Study. Creativecommons.org/licenses/by/2.5/13-04-09. tumors defines cancer gene targets. Proc. Natl. Acad. Sci. USA 2006, 103:2257-61.

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Lawrie CH. MicroRNAs and haematology: small molecules, big function. Br J Haematol

high-risk regions of Kenya. International Journal of Cancer 2006, 120: 121-127. 2007, 137:503-12.

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Leoncini L, Raphael M, Stein H et al. Burkitt lymphoma. World Health Organization 27.

Leucci E, Onnis A, Cocco M, De Falco G, Costanzo V, Bellan C, Lazzi S and Leoncini L.

Classification of Tumours: Tumours of Haematopoietic and Lymphoid tissues, 262-264. Jaffe Altered hsa-miR-127 expression impairs terminal B cell differentiation in EBV-positive

ES, Harris NL, Stein H, Vardimar JW, eds. IARC Press: Lyon 2008. Burkitt lymphoma. Int J Cancer 2010, 126:1316-26.

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Levine AM. AIDS-related lymphoma. Semin. Oncol. Nurs 2006, 22:80–89. 28.

Giulia De Falco, Giuseppina Antonicelli, Anna Onnis, Cristiana Bellan, Stefano Lazzi and

12.

Noy A. Update in HIV lymphoma. Curr. Opin. Oncol 2006, 18:449–455. Lorenzo Leoncini. Role of EBV in microRNA dysregulation in Burkitt lymphoma.

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Spina D, Leoncini L, Megha T, Gallorini M, Disanto A, Tosi P, Abinya O, Nyong'O A, Pileri Seminars in Cancer Biology 2009, 19:401-6.

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S, Kraft R, Laissue JA, Cottier H. Cellular kinetic and phenotypic heterogeneity in and A. Onnis, G. De Falco, E. Rogena, F. Morettini, C. Bellan, L. Leoncini. MicroRNA

among Burkitt's and Burkitt-like lymphomas. J Pathol. 1997, 182:145-50. expression profile identifies a different signature between MYC translocation-positive

14.

Cinti C, Leoncini L, Nyongo A, Ferrari F, Lazzi S, Bellan C, Vatti R, Zamparelli A, Cevenini and negative Burkitt Lymphoma cases. (Submitted).

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G, Tosi GM, Claudio PP, Maraldi NM, Tosi P, Giordano A. Genetic alterations of the Pier Paolo Piccaluga, Giulia De Falco, Manjunath Kustagi, Anna Gazzola, Annalisa

retinoblastoma-related gene RB2/p130 identify different pathogenetic mechanisms in Astolfi, Anna Onnis, Eleonora Leucci, Maria Rosaria Sapienza, Valeria Calbi, Michael

and among Burkitt's lymphoma subtypes. Am J Pathol. 2000, 156:751-60. Mawanda, Lynnette Tumwine, Claudio Agostinelli, Cristiana Bellan, Stefano Lazzi,

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Lazzi S., Bellan C., De Falco G., Cinti C., Ferrari F., Nyongo A., Claudio P.P., Tosi G.M., Vatti Claudio Tripodo, Martin Ogwang, Andrea Califano, Riccardo Dalla Favera, Stefano A

R., Gloghini A., Carbone A., Giordano A., Leoncini L. and Tosi P. Expression of RB2/p130 Pileri and Lorenzo Leoncini. Gene expression analysis uncovers similarity and

tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for differences in endemic and sporadic Burkitt lymphomas molecular profiles. Blood 2011,

disease pathogenesis. Hum Pathol 2002, 33:723-31. 117:3596-608.

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De Falco, G., Bellan, C., Lazzi, S., Claudio, P.P., La Sala, D., Cinti, C., Tosi, P., Giordano, A. Dido Lenze, Lorenzo Leoncini, Michael Hummel, Stefano Volinia, Chang Gong Liu, Teresa

and Leoncini L. Interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in Amato, Giulia De Falco, Jessie Githanga, Heike Horn, Joshua Nyagol, German Ott, Jeff

the pathogenesis of AIDS-related neoplasms. Oncogene 2003, 22:6214-9. Pallatini, Michael Pfreundschuh, Emily Rogena, Andreas Rosenwald, Reiner Siebert,

Carlo M Croce, Harald Stein. The different epidemiologic subtypes of Burkitt Lymphoma

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G. De Falco, E. Leucci, D. Lenze, P.P. Piccaluga, P.P. Claudio, A. Onnis, G. Cerino, J. Nyagol,

share a largely homogenous micro RNA profile distinct from diffuse large B-cell

CANCER CONTROL 2013 81

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